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BoneReg-Inject™

Orthopedic surgery relies on technology to compensate for loss of bone tissue in trauma and ostectomies or to promote bone formation in fusion procedures. The golden standard of enhancing bone formation is autologous bone graft, usually harvested from the pelvis, causing morbidity and clinical complications. Products currently offered to solve this problem are either bone void fillers and bone graft extenders which lack sufficient osteogenic activity, or osteoinductive bone graft substitutes featuring human recombinant bone specific growth factors (rhBMPs) which are faced with significant price and safety issues. BoneReg-Inject™ effectively addresses the market need for osteoconductive and osteogenic bone graft substitutes by safely and efficiently sustaining in situ osteogenesis, thus eliminating the need for autologous bone grafts or bone marrow aspirates.

Efficiently induces bone healing without scar tissue formation

BoneReg-Inject™ induces scar-less healing in bone defects through a process of intramembraneous and endochondral bone formation. Vascularized fibrous layer is formed on the surface of the implant fostering differentiated osteoblasts laying down new bone surrounding the BoneReg-Inject implant. (Proximal tibia in a geriatric sheep model, 3 months post op.)

Provides Scaffold for new bone formation

The BoneReg-Inject™ implant is rapidly colonized by dense cancellous lamellar bone structures comprising channels of new bone marrow. (Proximal tibia in a geriatric sheep model, 3 months post op.)

Provides environment for endochondral bone formation

Islands of endochondral bone formation occur scattered throughout the BoneReg-Inject™ implant producing mature bone with healthy extracellular matrix. (Proximal tibia in a geriatric sheep model, 3 months post op.)

Fully biocompatible providing sustained osteogenesis

Consistent and sustained osteogenesis inside the BoneReg-Inject implant is observed during 13 months post operative. The new bone is scattered throughout the implant surrounding channels of bone marrow tissue and characterized by mature extracellular matrix exhibiting lamellar structure. (Proximal tibia in a geriatric sheep model, 13 months post op.)